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Index > Protein center > Pck1(Gene name) > Rat
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  • Pck1 (Gene name),
  • Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (Protein name ),  PCKGC_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Pck1;
    Protein name:
    Phosphoenolpyruvate carboxykinase, cytosolic [GTP](PEPCK-C);
    Alternative:
    Phosphoenolpyruvate carboxylase;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    622
    Sequence:
    50:
    MPPQLHNGLD | FSAKVIQGSL | DSLPQEVRKF | VEGNAQLCQP | EYIHICDGSE | 
    100:
    EEYGRLLAHM | QEEGVIRKLK | KYDNCWLALT | DPRDVARIES | KTVIITQEQR | 
    150:
    DTVPIPKSGQ | SQLGRWMSEE | DFEKAFNARF | PGCMKGRTMY | VIPFSMGPLG | 
    200:
    SPLAKIGIEL | TDSPYVVASM | RIMTRMGTSV | LEALGDGEFI | KCLHSVGCPL | 
    250:
    PLKKPLVNNW | ACNPELTLIA | HLPDRREIIS | FGSGYGGNSL | LGKKCFALRI | 
    300:
    ASRLAKEEGW | LAEHMLILGI | TNPEGKKKYL | AAAFPSACGK | TNLAMMNPTL | 
    350:
    PGWKVECVGD | DIAWMKFDAQ | GNLRAINPEN | GFFGVAPGTS | VKTNPNAIKT | 
    400:
    IQKNTIFTNV | AETSDGGVYW | EGIDEPLAPG | VTITSWKNKE | WRPQDEEPCA | 
    450:
    HPNSRFCTPA | SQCPIIDPAW | ESPEGVPIEG | IIFGGRRPAG | VPLVYEALSW | 
    500:
    QHGVFVGAAM | RSEATAAAEH | KGKVIMHDPF | AMRPFFGYNF | GKYLAHWLSM | 
    550:
    AHRPAAKLPK | IFHVNWFRKD | KNGKFLWPGF | GENSRVLEWM | FGRIEGEDSA | 
    600:
    KLTPIGYVPK | EDALNLKGLG | DVNVEELFGI | SKEFWEKEVE | EIDKYLEDQV | 
    622:
    NADLPYEIER | ELRALKQRIS | QM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat PEPCK-C
    Cat.:
    E0936m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat PEPCK-C
    Cat.:
    E0936r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat PEPCK-C
    Cat.:
    E0936h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat PEPCK-C
    Cat.:
    E0936c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PEPCK-C
    Cat.:
    U0936r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PEPCK-C
    Cat.:
    U0936m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PEPCK-C
    Cat.:
    U0936h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat PEPCK-C
    Cat.:
    U0936c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat PEPCK-C
    Polyclonal Antibody for Rat PEPCK-C
    Cat.:
    P0936Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PEPCK-C
    Cat.:
    P0936Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PEPCK-C
    Cat.:
    P0936Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat PEPCK-C
    Monoclonal Antibody for Rat PEPCK-C
    Monoclonal Antibody for Rat PEPCK-C
    Monoclonal Antibody for Rat PEPCK-C
    Protein for Rat PEPCK-C
    Protein for Rat PEPCK-C
    Protein for Rat PEPCK-C
    Protein for Rat PEPCK-C

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    References
    1. 1.
      "Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene."
      Beale E.G. , Chrapkiewicz N.B. , Scoble H.A. , Metz R.J. , Quick D.P. , Noble R.L. , Donelson J.E. , Biemann K. , Granner D.K.
      J. Biol. Chem.260:10748-10760(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Liver.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    3. 3.
      "Cysteine 288: an essential hyperreactive thiol of cytosolic phosphoenolpyruvate carboxykinase (GTP)."
      Lewis C.T. , Seyer J.M. , Carlson G.M.
      J. Biol. Chem.264:27-33(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 279-290;ACTIVE SITE CYS-288
      tissue: Liver.
    4. 4.
      "Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin."
      Sasaki K. , Cripe T.P. , Koch S.R. , Andreone T.L. , Petersen D.D. , Beale E.G. , Granner D.K.
      J. Biol. Chem.259:15242-15251(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    5. 5.
      "Inhibition of glucagon-signaling and downstream actions by interleukin 1beta and tumor necrosis factor alpha in cultured primary rat hepatocytes."
      Christ B.
      Horm. Metab. Res.40:18-23(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    6. 6.
      "Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid."
      Sullivan S.M. , Holyoak T.
      Biochemistry46:10078-10088(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF APOENZYME AND IN COMPLEX WITH MANGANESE; GTP AND SUBSTRATE;COFACTOR;REACTION MECHANISM
    7. 7.
      "Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection."
      Sullivan S.M. , Holyoak T.
      Proc. Natl. Acad. Sci. U.S.A.105:13829-13834(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF APOENZYME AND IN COMPLEX WITH MANGANESE; GTP AND SUBSTRATE;COFACTOR;REACTION MECHANISM
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